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What is osteogenesis imperfecta (brittle bone disease)?

Osteogenesis imperfecta, commonly known as brittle bone disease, is a lifelong genetic condition affecting the body’s ability to make collagen protein, causing fragile and brittle bones. Without the right amount of collagen, bones are weak and highly susceptible to trauma, causing frequent fractures and breaks. Common symptoms of the condition are frequent broken bones, gradual bending of the leg and arm bones, short stature, weak muscles, and, in time, loss of the ability to walk.

What issues do children with brittle bones face?



Weakened bones can lead to abnormal bending, painful breaks, and fractures



Children with frequent broken bones are vulnerable to bullying and exclusion



Children can lose the ability to walk, preventing them from attending school

How does surgery change a child’s life?

  • The condition can be managed, though not cured, through intravenous medicine to strengthen the bones (bisphosphonates) and surgery to straighten the bones.
  • Children experience restored confidence and hope as they are accepted into community life.
  • Mobility improves so children can run, play, walk pain-free, completing school which lead to more opportunities.

Miracles happen every day at CURE Children’s Hospital of Niger


Farida and her two sisters share the same condition that prevents them from walking or playing outside. At CURE Niger, they’re receiving the care they need. After multiple surgeries and months of therapy–and lots of love– at CURE, Farida can walk and dance!

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CURE Niger’s mission is to provide every child living with a disability the physical, emotional, and spiritual care they need to heal. If you have questions about becoming a patient or a partner with CURE, please contact us.

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